Wholes are real, or else they are not worth talking about at all, as not existing in the first place. On materialism, there are no wholes: no persons, no molecules, not even any Rutherfordian atoms or protons.
So then, on materialism, most human discourse is – as pertaining to entities that do not truly exist, being therefore inapposite to things as they really are – simply not worth doing; is, rather, inapt, and so likely injurious.
But if materialism is false – as, being a notion of entities that under its own account do not actually exist, it must necessarily be – then wholes are real. Some of them, anyway. The trick is to discern which apparent wholes are entities in their own right, and which are only our own heuristics.